According to the universiry research, NK Stimu results show it can inhibit Glucose-regulated protein 78 (GRP78), Interleukin-6 (IL-6), and Tumor Necrosis Factor (TNF-α), significantly reducing pulmonary edema in mice by up to 80%. High levels of GRP78 can cause immune system disorders/cytokine storms. When many countries were ravaged by the SARS-CoV-2 virus, medical findings showed that infected patients had significantly elevated GRP78 levels in their blood and lungs, triggering pneumonia and pulmonary fibrosis, leading to reduced lung capacity and decreased blood oxygen levels. GRP78 is soluble and can form complexes with viral particles, affecting patients' respiratory systems and various organs, including kidneys, heart, liver, brain, and pancreas. 

GRP78 is a molecular chaperone protein in the cell's Endoplasmic Reticulum (ER), responsible for proper protein folding and preventing new peptide aggregation in the ER. When the ER experiences oxidative stress, it disrupts GRP78's normal function and causes calcium ion imbalance, leading to pathological processes including gene mutations, Tau phosphorylation, and β-amyloid formation. This further promotes cholesterol and lipid level disorders, increasing the risk of high blood pressure, high blood sugar, and high cholesterol. Recent scientific research shows that ER oxidative stress leads to accumulation and deposition of Unfolded Proteins (URP) in cells. These abnormal proteins, called β-Amyloid, disrupt normal neuronal signal transmission and induce neuronal damage, leading to Alzheimer's disease. In recent years, biologists have extensively focused on the relationship between GRP78 expression and fatty liver, diabetes, cardiovascular disease, and tumor growth, while continuing key research on GRP78 pathways as a new direction for cancer treatment.

Ingredients : Sweet  Almond Oil, Black Seed Oil, Avocado Oil, Sesame Oil, Eucalyptus, Lemon Organic, Tea Tree Organic, Geranium, Rosewood, Sandalwood, Ginger, Vitamin A & E

According to the unviersity research, Cytophoxin has shown good effects in inhibiting Matrix Metalloproteinase-3 (MMP-3), Leukotriene B4 (LTB4), Alanine Aminotransferase (ALT), and Tumor Necrosis Factor-alpha (TNF-α). It has demonstrated the ability to prevent liver cancer cell spread and reduce tumor volume by up to 60%. 

MMP-3 is a matrix-dissolving enzyme that causes calcification and inflammatory damage to bone collagen, connective tissue, and blood vessels. It leads to cartilage matrix degeneration, atherosclerosis, rheumatic heart disease development, and promotes angiogenesis that assists cancer cell spread. When MMP-3 develops in the blood-brain barrier, it can cause damage and permeability leakage, leading to fluid accumulation and cerebral edema. 

The Substantia Nigra (SN) is one of the main pathways for dopamine. If MMP-3 continues to develop in the SN, it can inhibit dopamine secretion, affecting autonomous motor function and leading to uncontrollable movements such as hand and foot tremors. Additionally, other brain regions including the prefrontal cortex, olfactory cortex, cingulate gyrus, basal ganglia, and other areas require dopamine neurotransmitter signaling. Insufficient dopamine secretion can affect memory, concentration, and lead to overall functional decline.

Cytophoxin CO2 Extract, Kakadu Plum, Artichoke, Pine Bark Extract, Green Tea Extract, Tender Catchweed Bedstraw, Cat’s Claw, Methylsulfonylmethane

According to the unviersity research, Calmtitine results show it increases in central nervous system GABA (Gamma Aminobutyric Acid) and serotonin (5-HT) concentrations. It can inhibit the excitatory neurotransmitter glutamate (Glu) and reduce aspartic acid (Asp) levels in the brain, while prolonging seizure latency and shortening epileptic episodes. It demonstrates good antiepileptic effects and protects the central nervous system from damage, while also helping to relieve excessive tension and stress. 

Alzheimer's disease (AD) and epilepsy are common neurological disorders in elderly people, with epilepsy potentially occurring in both early and late stages of AD. In Alzheimer's patients, the hippocampus shows granule cell loss in the dentate gyrus (DG), mainly due to beta-amyloid (Aβ) deposits and accumulation of hyperphosphorylated Tau protein in neurofibrillary tangles. These changes cause neural network alterations with excessive excitatory glutamate activity and insufficient release of the inhibitory neurotransmitter GABA. This imbalanced mechanism leads to brain toxicity damage, resulting in overactive sympathetic nervous system, rapid heartbeat, high blood pressure, insomnia, uncontrolled muscle rigidity, drooping eyelids, convulsions, confused shouting, involuntary nodding, dilated pupils, high fever, or tremors. More severe cases may present risks of seizures or epilepsy.

Ingredients : Sweet  Almond Oil, Black Seed Oil, Avocado Oil, Sesame Oil, Frankincense, Chamomile,  Sweet Orange, Lavender, Magnolia, Vitamin A & E

According to the unviersity research, D’pa Build results show it helps promote Tyrosine Hydroxylase (TyrH) synthesis, revives and extends the life of oxidized neurons, and helps improve eGFR (glomerular filtration rate). Research on D’pa Build's promotion of TyrH also revealed anti-epileptic effects, significantly reducing seizures and extending the latency period with good protective effects. 

Dopamine, known as the "positive energy" neurotransmitter, coordinates cerebral cortex functions in the central nervous system and acts as a local paracrine messenger. Dopamine plays a crucial role in kidney function by increasing blood supply and eGFR, helping remove excess sodium and heavy metals through urine to stabilize blood pressure. Additionally, dopamine helps reduce excessive gastrointestinal motility, protecting the digestive tract walls. 

TyrH is a crucial enzyme for dopamine precursor synthesis, catalyzing L-DOPA synthesis in the brain to cross the blood-brain barrier. TyrH deficiency blocks neurotransmitter transmission, leading to various diseases due to the lack of dopamine, norepinephrine, epinephrine (catecholamines), and serotonin in both central and peripheral nervous systems. TyrH deficiency can trigger conditions like TH-Deficient Dopa-Responsive Dystonia (DRD) or Infantile Encephalopathy. Symptoms include limb dystonia, movement disorders such as tremors or rigidity affecting gait and posture coordination, and rare cases of Parkinson's disease in children. In sub-healthy individuals, TyrH deficiency can lead to symptoms including hypertension, high uric acid, edema, creatinine issues, emotional instability, insulin intolerance, attention deficit, multiple sclerosis, proteinuria, urinary frequency or difficulty, glaucoma, weight gain, and glucose intolerance. More severe cases may develop into cognitive impairment or Parkinson's disease.

Ingredients : Linalool,  Geraniolα-Terpineol, 1,8-Cineol

According to the unviersity research, Hepalans results show effective reduction in Alanine Aminotransferase (ALT) and Caspase-3 activity, while simultaneously inhibiting Leukotriene B4, C4 (LT) and Tumor Necrosis Factor  (TNF-α), and balancing hepatic cytochrome CYP450 system 2E1. 

Caspase-3, known as the "sword of death," primarily promotes cellular aging and apoptosis. Scientific research indicates that Caspase-3 activation leads to the cleavage of β-Amyloid precursor protein (APP), further forming extracellular senile plaques and intracellular protein tangles, which are the main pathological features of AD neurodegenerative disease. ALT, a liver function indicator, is recommended by the World Health Organization as the most sensitive marker for liver damage. Elevated ALT levels indicate mitochondrial damage in the liver. New psychogeriatric research has found that higher ALT levels correlate with right hippocampal atrophy, which can lead to cognitive dysfunction and memory decline, directly linked to Alzheimer's disease. Furthermore, high ALT levels can increase the risk of metabolic disorders such as cardiovascular disease, fatty liver, alcoholic liver disease, hepatitis, cirrhosis, or liver cancer.